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Interleukin-1 Receptor Antagonist Protein, IRAP, is an autologous conditioned serum used by veterinarians to manipulate the body's biological mechanisms to treat joint disease or degenerative joint disease. Molecular biology has identified the major inducer of osteoarthritis being a general inflammatory cytokine interleukin-1 (IL-1) which plays a key role in accelerating tissue destruction and the repair mechanisms.
Osteoarthritis is a common musculoskeletal cause of lameness in a horse. Clinical signs can include joint swelling from cartilage damage or inflammation of the joint lining or synovitis. The traumatized joint can release IL-1 and IRAP helps to block this protein from producing additional damage. In a healthy joint, IL-1 and interleukin-1 receptor antagonist (IL-1Ra) are in balanced concentrations. In cases of osteoarthritis, there is not sufficient IL-1Ra produced to block the destructive effects of the increased IL-1. The result is inflammation, joint pain, and eventually cartilage destruction.
The IRAP process includes drawing blood into a 60 ml syringe which contain glass beads. The glass beads attract and bind monocytes (a type of white blood cell). The cells are then stimulated to produce regenerative and anti-inflammatory proteins without the addition of drugs. This process takes place over an incubation period of 24 hours. Once incubation is complete, centrifugation is performed to remove the red blood cells. The remaining serum is split into individual doses. Joint injections are then completed every other week for three treatments and a remaining dose or two remain frozen at -20F for future treatments
A few products are on the market including IRAP, IRAP II, and Pro-Stride. Research has compared IRAP and IRAP II and concluded that IRAP II has a modestly improved cytokine profile but both products produced a significant increase in IL-1Ra. We are happy to provide IRAP II at our veterinary practice.
I just want to take this time to say THANK YOU for finally giving me some answers regarding Denver's lameness.
Since March/April 2015 until now (December 2015), we have been getting mixed diagnosis as to why he would be off, but you came and gave us hope. More importantly, I want to THANK YOU for your patience and amazing 'bedside' manner. Not only did you provide me with solid information and demonstration of compression, and how his conformation defect was affecting his way of going, but you were meticulous in your explanation of the benefits of acupuncture for Denver. You explained everything in such a way, that I would be able to not only understand but remember, and then be able to explain it to all those at our barn who were genuinely concerned about how he's doing or how the Vet visit went. You made me feel very much at ease, like my opinion as his owner mattered, as you would say, "That's good information. Thank You for that" Now, that's a first; the VET Thanking me!! Never once did you make it seem like my questions were irrelevant. You gave us your undivided attention as if we were your only clients that day, and I know we were not because Jessica reminded/alerted you of the time, but you never flinched, never took your eyes off of me as you were explaining everything you did with Denver, and never once appeared rushed. The whole experience of your visit left me committing to making you our Vet of choice. Denver means a lot to me, and the way you treated him, made me think he was more than just a client/horse to you. I can't THANK YOU enough Dr. Sobota!
Ps. By the way, Jessica is an Awesome assistant, and Danielle is Grrr8!!
Dr. Justin and his staff have been our vets for several years now. He has done everything from pre-purchase exams and lameness evaluations to dentals. Each and every time, he and his staff are timely, knowledgeable, and considerate. Their passion for the horses as well as consideration of the owners and barn management is unmatched.
Finally, after looking for years, we found a farm vet with the sophistication and feel for lameness of the vets at the big national-caiber ship-in clinics and equine hospitals. Dr. Justin (Sobota) has great instincts and is well versed in the cutting-edge aspects of equine veterinary medicine, as well as a host of alternative therapies like acupuncture and chiropractic treatments. He asks important questions of and listens well to those who know the horse best, always offers a range of therapeutic options, and thoroughly explains his expectations for treatment results. Perhaps most refreshing, however, is how friendly, helpful and accommodating Dr. Justin and his staff are. We feel lucky to have Dr. Justin as an important part of the Finer Points Farm family.
Dr. Justin Sobota, and his team at South Mountain Equine, are highly skilled, professional, courteous, and helpful. Dr. Sobota has managed our mare in several very difficult clinical situations where diagnosis and treatment were not immediately obvious. He worked diligently to find the source of the problem, spending whatever time necessary with the horse and listening patiently to her owners, until the diagnosis was clear and treatment in place. This is the first practice I’ve dealt with that followed up until the problem was resolved. The follow up extends to routine visits, such as vaccines, as well. South Mountain and Dr. Sobota are always quick to respond to emergency or routine concerns. This level of skill and caring provides a level of support for an owner that results in peace of mind.
Dr. Justin Sobota and South Mountain Equine offer horse owners peace of mind. They are easily accessible to reach for concerns and always willing to talk with owners. Dr. Sobota and his staff are knowledgeable and caring, including their efforts when it comes to follow-up care. After a recent surgical procedure, Dr. Sobota checked in everyday for the first week and still checks in weekly. I would recommend South Mountain Equine to any horse owner.